Basal/squamous and Mixed subtype bladder cancers present poor outcomes after neoadjuvant chemotherapy in the VESPER trial

C.S. Groeneveld (1, 2, 3) , C. Pfister (4) , S. Culine (5) , V. Harter (6) , C. Krucker , J. Fontugne , V. Dixon , N. Sirab , I. Bernard-Pierrot , A. de Reyniès , F. Radvanyi (2) , Y. Allory (7, 8) , G. Pignot (9) , J.P. Fendler (10) , L. Guy , G. Verhoest (11, 12) , N. Mottet (13) , A. Doerfler (14) , S. Abadie-Lacourtoisie , A. Azzouzi (15) , P. Mongiat , L. Geoffrois , P. Eschwege , F. Di Fiore , G. Roubaud , J.L. Hoepffner , P. Barthelemy , H. Lang , E. Voog , E. Mandron , J.M. Tourani , C. Serrrate , A. Colau , C. Saldana , A. de La Taille , T. Nguyen , F. Kleinclauss , Y. Loriot , J. Irani , J.C. Eymard , S. Larre , O. Huillard , M. Zerbib , F. Rolland , J. Rigaud , N. Houede , S. Droupy , G. Malouf , M. Roupret , S. Vieillot , N. Letang , T. Lharidon , N. Gaschignard , W. Hilgers , J.L. Davin

1 CRC (UMR_S_1138 / U1138) - Centre de Recherche des Cordeliers
2 Biologie Cellulaire et Cancer
3 Equipe labellisée Ligue contre le Cancer
4 Service d'urologie [Rouen]
5 Hôpital Saint-Louis
6 UNICANCER/CRLC - Centre Régional de Lutte contre le Cancer François Baclesse [Caen]
7 UVSQ - Université de Versailles Saint-Quentin-en-Yvelines
8 Institut Curie [Paris]
9 IPC - Institut Paoli-Calmettes
10 Centre hospitalier Saint Joseph - Saint Luc [Lyon]
11 Cancer du rein : bases moléculaires de la tumorogenèse
12 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
13 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
14 CHU - Centre Hospitalier Universitaire Brugmann [Bruxelles]
15 CHU Angers - Centre Hospitalier Universitaire d'Angers

 Tumors of 'Mixed' molecular subtype, which are spatially heterogeneous, represent 16% of MIBCs in the VESPER cohort  Ba/Sq (pure or mixed) have poor outcomes post-NAC compared to other Consensus subtypes (HR=2.0, 95% CI 1.36-3.0, p<0.001)  Tumors of partial or non-responders to NAC with Ba/Sq subtype (pure or mixed) maintain their Ba/Sq phenotype at cystectomy

Mots clés: molecular subtype; intra-tumor heterogeneity; basal subtype; prognosis

Domaines: Sciences du Vivant [q-bio]

C.S. Groeneveld, C. Pfister, S. Culine, V. Harter, C. Krucker, et al.. Basal/squamous and Mixed subtype bladder cancers present poor outcomes after neoadjuvant chemotherapy in the VESPER trial. Annals of Oncology, 2024, ⟨10.1016/j.annonc.2024.09.008⟩. ⟨hal-04780573⟩